Silvio De Flora Selected Research

Chemoprevention

1/2020	Modulation of smoke-induced DNA and microRNA alterations in mouse lung by licofelone, a triple COX-1, COX-2 and 5-LOX inhibitor.
12/2015	Modulation by aspirin and naproxen of nucleotide alterations and tumors in the lung of mice exposed to environmental cigarette smoke since birth.
1/2015	Modulation by licofelone and celecoxib of experimentally induced cancer and preneoplastic lesions in mice exposed to cigarette smoke.
1/2014	Rationale and approaches to the prevention of smoking-related diseases: overview of recent studies on chemoprevention of smoking-induced tumors in rodent models.
1/2013	Chemoprevention of doxorubicin-induced alopecia in mice by dietary administration of L-cystine and vitamin B6.
10/2012	MicroRNAs as targets for dietary and pharmacological inhibitors of mutagenesis and carcinogenesis.
3/2010	Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine.
1/2010	Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention.
6/2007	Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin B6.
7/2006	Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005.

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Silvio De Flora Research Topics

Disease

55	Neoplasms (Cancer) 01/2020 - 01/2002
27	Carcinogenesis 01/2018 - 04/2002
12	Inflammation (Inflammations) 01/2020 - 10/2004
10	Adenoma (Adenomas) 01/2018 - 12/2008
10	Lung Neoplasms (Lung Cancer) 12/2016 - 02/2003
7	Body Weight (Weight, Body) 01/2020 - 04/2002
4	Emphysema 12/2016 - 06/2003
4	Hyperplasia 12/2016 - 01/2013
4	Alopecia (Baldness) 01/2013 - 05/2006
3	Breast Neoplasms (Breast Cancer) 01/2018 - 12/2005
3	Lung Diseases (Lung Disease) 12/2016 - 09/2009
3	Carcinoma (Carcinomatosis) 12/2011 - 03/2005
3	Glaucoma 01/2006 - 01/2003
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 07/2015 - 06/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015 - 10/2011
2	Cardiovascular Diseases (Cardiovascular Disease) 03/2011 - 09/2008
2	Chronic Obstructive Pulmonary Disease (COPD) 03/2011 - 07/2009
1	COVID-19 10/2020
1	Human Influenza (Influenza) 10/2020
1	Papilloma (Papillomatosis) 01/2018
1	Adenocarcinoma 12/2015
1	Hepatocellular Carcinoma (Hepatoma) 07/2015
1	Infections 07/2015
1	HIV Infections (HIV Infection) 07/2015
1	Pulmonary Emphysema 01/2015
1	Chronic Disease (Chronic Diseases) 01/2014
1	Neoplasm Metastasis (Metastasis) 12/2012
1	Pneumonia (Pneumonitis) 12/2011
1	Virus Diseases (Viral Diseases) 07/2011
1	Communicable Diseases (Infectious Diseases) 06/2011

Drug/Important Bio-Agent (IBA)

34	SmokeIBA 01/2020 - 02/2002
14	MicroRNAs (MicroRNA)IBA 01/2020 - 03/2009
10	DNA (Deoxyribonucleic Acid)IBA 06/2014 - 01/2003
9	Acetylcysteine (Siran)FDA LinkGeneric 10/2020 - 01/2002
8	Biomarkers (Surrogate Marker)IBA 12/2016 - 02/2002
7	AntioxidantsIBA 10/2020 - 03/2005
7	CarcinogensIBA 01/2020 - 12/2005
6	Estrogens (Estrogen)FDA Link 01/2018 - 07/2011
6	chromium hexavalent ionIBA 01/2016 - 04/2002
6	Proteins (Proteins, Gene)FDA Link 01/2015 - 10/2004
5	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2020 - 01/2015
5	Pharmaceutical PreparationsIBA 01/2020 - 10/2004
4	DNA AdductsIBA 01/2020 - 08/2007
4	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 09/2018 - 10/2004
4	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2018 - 12/2015
4	Complex MixturesIBA 06/2014 - 02/2003
4	ProteomeIBA 10/2013 - 12/2005
4	Glutathione (Reduced Glutathione)IBA 03/2010 - 04/2002
3	8-Hydroxy-2'-DeoxyguanosineIBA 01/2020 - 06/2003
3	NucleotidesIBA 01/2020 - 01/2003
3	Naproxen (Naprosyn)FDA LinkGeneric 10/2017 - 12/2015
3	salicylhydroxamic acid (SHAM)IBA 01/2013 - 12/2008
3	phenethyl isothiocyanate (PEITC)IBA 05/2010 - 06/2009
3	Budesonide (Pulmicort)FDA LinkGeneric 03/2010 - 05/2006
2	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2020 - 01/2015
2	licofeloneIBA 01/2020 - 01/2015
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2020 - 10/2017
2	Celecoxib (Celebrex)FDA Link 09/2018 - 01/2015
2	Ethanol (Ethyl Alcohol)IBA 12/2016 - 01/2016
2	Tyrosine Kinase InhibitorsIBA 10/2014 - 01/2010
2	Vitamin B 6IBA 01/2013 - 06/2007
2	Cystine (L-Cystine)IBA 01/2013 - 06/2007
2	Drinking WaterIBA 09/2009 - 11/2006
2	HalogensIBA 12/2008 - 03/2005
2	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2007 - 01/2006
2	MutagensIBA 08/2007 - 12/2005
2	sodium bichromate (sodium dichromate)IBA 11/2006 - 04/2002
1	CytosineIBA 01/2020
1	Histones (Histone)IBA 01/2020
1	4- (N- methyl- N- nitrosamino)- 1- (3- pyridyl)- 1- butanoneIBA 01/2020
1	LipopolysaccharidesIBA 01/2020
1	Cyclooxygenase 1IBA 12/2015
1	Transcription Factor 4IBA 12/2015
1	VaccinesIBA 07/2015
1	Antiviral Agents (Antivirals)IBA 07/2015
1	Combined VaccinesIBA 07/2015
1	Amyloid (Amyloid Fibrils)IBA 01/2015
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2015
1	Lapatinib (GW572016)FDA Link 10/2014
1	ErbB Receptors (EGF Receptor)IBA 10/2014
1	human ERBB2 proteinIBA 10/2014
1	Metformin (Glucophage)FDA LinkGeneric 06/2014
1	Bexarotene (LGD1069)FDA Link 10/2013
1	Pioglitazone (Actos)FDA Link 10/2013
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2013
1	Vorinostat FDA Link 01/2013
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2013
1	Histone Deacetylase InhibitorsIBA 01/2013
1	Oxidants (Oxidizing Agents)IBA 10/2011
1	Biological ProductsIBA 07/2011
1	Particulate MatterIBA 03/2011
1	Coal AshIBA 03/2011
1	Estrogen Receptor betaIBA 03/2010
1	Monoclonal AntibodiesIBA 01/2010

Therapy/Procedure

16	Chemoprevention 01/2020 - 01/2004
7	Oral Administration 10/2020 - 04/2002
5	Therapeutics 10/2020 - 12/2005
3	Secondary Prevention 12/2016 - 12/2005
2	Drug Therapy (Chemotherapy) 01/2013 - 01/2010
2	Tertiary Prevention 06/2011 - 12/2005